4.7 Tesla atlas

4.7 Tesla MRI Atlas of Human Deep Brain

Human brain stereotactic atlases are widely used in stereotactic neurosurgery for indirect anatomical targeting, when medical imaging cannot reveal directly the spot. Following a 4.7-Tesla MRI acquisition of the deep brain of an anatomic specimen, we contoured and labeled 100 anatomic objects, lending to an extended anatomical 3D MRI atlas. This is the first 3D anatomic atlas detailing the deep brain. An Industrial transfer is ongoing. Since 2013 we are developing the analysis of the upper brain stem notably the tegmental region, showing complex anatomical structure such as reticular nuclei for future clinical studies (e.g. gait control).

Fig. 1: 4.7-Tesla MRI atlas centered on the thalamus; clock-wise from left-top (Iplan software, BrainLab, Germany), 3D display of anatomic objects (medial view; anterior-posterior line or ACPC line, is projected), horizontal (axial) slice, vertical-frontal (coronal) slice and vertical-sagittal slice, going through the nucleus ventrointermedius of thalamus (Vim, blue); (yellow, pulvinar; lateral and medial ventro-lateral nuclei, dark and light pink; centromedian (red); ventro-oral nuclei, blue).

Fig. 2: 4.7-Tesla MRI atlas centered on the nucleus tegmental pedunculopontine; reconstructed pseudo-coronal slice (Iplan software, BrainLab, Germany) along the line perpendicular to the vertical line of Paxinos & Huang and going through the nucleus tegmental pedunculopontine of the lateral reticular system (ppn, yellow); (brachium conjunctivum, orange; medial and lateral lemniscuses, light and dark blue; spino-thalamic fascicle, light green).